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SRP. 2020; 11(10): 1066-1079

The Effect of Lumbricus Rubellus Extracts on IL-4, IL-10, IgE, and Eosinofil Levels in Atopic Dermatitis Patient

Farida Tabri, Pipim Septiana Bayasari, Rosani Sri Camelia, Anis Irawan Anwar, Anni Adriani, Farida Ilyas.


Atopic dermatitis is a chronic, residive inflammatory skin condition characterized by severe pruritus. Pathophysiology of AD is a multifactorial, skin barrier disorder, and involves altered immune response, it can be seen in rural population which exposed from many worm infections with a low prevalence of allergic disease and has been shown in animal models by stimulating the formation of TGF β and interleukin-10 (IL-10) inhibiting IL-4, IL-5, IL13 by stimulating Treg. To determine the effect of Lumbricus Rubellus extract, it can increase interleukin 10 and reduce IL-4, immunoglobulin E and eosinophils and it can provide clinical improvement in Atopic Dermatitis patients. This research used "Pretest-Posttest Design" method of mild atopic dermatitis patients who were not infected with worms. Lumbricus Rubellus extract was given for 2 weeks and checked for eosinophils and ELISA to determine IL-10 and IgE levels on day 0, 8 and 15. Statistical test used non-parametric tests, such as Mann-Whitney test (U-Test) and Wilcoxon test to determine whether there was a difference between two different treatments or not. There was a difference (p 0.05) there was still an increase in IL levels. -10 and decreased levels of IgE and eosinophil. The side effects that appeared at research were intestinal disorders, such as nausea and bowel disorders of a research subject. Lumbricus Rubellus extract has an immune response effect towards people with atopic dermatitis.

Key words: Earthworms, Lumbricus Rubellus, Atopic Dermatitis

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