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Research Article

JCDR. 2021; 12(6): 1247-1254

Study on Comparison of serial HRCT Chest severity with laboratory profile in COVID 19 patients admitted at a Tertiary Hospital in Central India

Ashutosh Kumar, Jai Kumar Gavli, Veerendra Arya, Arshi Ishteyaq, Raj Kumar Vishwakarma, Sohail Ahmed Ansari.


Background: COVID-19 is due to severe acute respiratory syndrome coronavirus 2 (SARSCoV2)
and was declared a global pandemic by World Health Organization. Various
biochemical parameters and serial High Resolution Computed Tomography (HRCT) chest
were used to evaluate the severity of the disease.
Aim & Objectives: The study was done to assess the association between biochemical
parameters and serial HRCT chest.
Material and Methods: It was a retrospective observational study at a tertiary hospital in
Central India. Patients >/= 18 years old admitted from 01 July 2020 to 31 December 2020
with laboratory-confirmed COVID-19 cases were included in the study. The laboratory
parameters included lymphopenia, neutrophil-lymphocyte ratio (NLR), C- Reactive protein
(CRP), Lactate Dehydrogenase (LDH), Ferritin, D– Dimer. Only Serial HRCT chest patients
were included in the study.
Results: In the study total of 44 patients (29 Males/15 Females) were taken. Serial HRCT
chest severity and biochemical markers severity were assessed, and the results were obtained.
It was found that there is a definite correlation between biochemical markers severity and
HRCT chest severity.
Conclusion: Since there was a definitive relationship between the severity of biochemical
markers and the severity of HRCT chest, biochemical profile can be utilized to determine
severity in the absence of HRCT chest.

Key words: Covid-19; Lymphopenia; NLR; LDH; CRP; Ferritin; D-dimer; HRCT chest

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