Objective: The aim of present study was designed to estimate level of plasminogen activator inhibitor -1 in liver cirrhotic patients, and its correlation with some biomarkers includes ( Liver enzymes: ALT,AST and Bilirubin ,Total protein, albumin. Methods: The current study include 30 Iraqi liver cirrhotic patients with age range 25-65 years and 30 healthy control subjects with age range 25-60 years. Results: The present study had been shown a high significant differences in liver enzymes ALT, AST and ALP when compare with control p≤ 0.01, 0.05 and 0.01 respectively. The difference in the mean serum level of albumin and total bilirubin were also observed to be highly significant in the liver cirrhosis patients p ≤ 0.01. Concerning mean serum level of PAI-1 in the liver cirrhosis patients a significant deference was found when compared to control with p≤0.05. Also there were a non-significant correlation between age and studied parameters Conclusions: The results of the present study showed a significant increase in serum levels of PAI-1 ALT,AST,ALP,T Bilirubin ,and Albumin while a non-significant differences in these parameters was shown in relation to age and gender.
Key words: liver cirrhosis, plasminogen activator inhibitor -1