This study was determined to verify that the combination of DFDBBX and mangosteen peel extract can increase the expression of bone morphogenetic protein-7 (BMP-7) and alkaline phosphatase (ALP) in tooth sockets on days 7 and 30 after extraction. The central lower incisors of Cavia cobaya were extracted using a needle holder, after which polyethylene glycol (PEG), DFDBBX + PEG, mangosteen peel extract + PEG, and a combination of DFDBBX + mangosteen peel extract + PEG were applied to the tooth socket. On days 7 and 30, the C. cobaya were sacrificed, their lower jaws were soaked in ethylenediaminetetraacetic acid and block paraffin, and a slide was made. Finally, an immunohistochemical examination of the expression of B MP-7 and ALP was performed. Statistical analysis by means of the analysis of variance indicated that each group was significantly different. The combination group showed the highest expression of BMP-7 and ALP on days 7 and 30, followed by the mangosteen peel extract group. A combination of DFDBBX and mangosteen peel extract 2% was applied to the C. cobaya tooth socket after extraction which increased the expression of BMP-7 and ALP on days 7 and 30.
Key words: DFDBBX, Garcinia mangostana, BMP-7, ALP, Medicine
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