Home|Journals|Articles by Year

Directory for Medical Articles

Original Article

Molecular Docking of Fucoidan (a polysaccharide compound Turbinaria conoides) with Carbonic anhydrase IX-A potent target molecule in Breast cancer

Revathi Chitra Santhanam, Syed Ali M, Anuradha V.


Turbinaria conoides is a type of brown seaweed containing Fucoidan, a complex polysaccharide. Fucoidan is known to have antiviral, antibacterial, antifungal and anticancer activity. The current study is focused on extraction of fucoidan from Turbinaria conides and the extracted fucoidan(FE) was confirmed by HPLC using standard fucose and the anti-scavenging property of the FE was determined by Ferric reducing antioxidant Power assay(FRAP) and Superoxide Dismutase(SOD). The structure of fucoidan was retrieved from Pubchem (CID 92023653) and it was allowed to dock against the carbonic anhydrase IX enzyme retrieved from (PDB ID 2HKF) which is up-regulated in breast cancer. FRAP and SOD showed significant anti-scavenging property compared to the standard and molecular docking analysis using the Molegro virtual docker (MVD5.0) of Fucoidan against the Carbonic Anhydrase IX (CA IX) showed significant binding affinity and hydrogen bond interactions with Molegro score -66.5818 with 8 H bonds having H-bond score of -18.8865.Fucoidan as a carbonic anhydrase IX inhibitor and consequently as a lead molecule against Breast Cancer can be further validated by suitable in vitro or in vivo investigation.

Key words: Carbonic anhydrase IX, Docking, Fucoidan, Insilico, Molegro virtual docker, and Turbinariaconoides.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.