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Research Article

ECB. 2019; 8(10): 335-338


CONDENSATION REACTION BETWEEN 3- ACETYLCOUMARINE AND ARYL ALDEHYDES IN THE PRESENCE OF L-PROLINE

Malihe Kamalpour, Farahnaz. K. Behbahani.




Abstract

3-Acetylcoumarine and a series a coumarin-chalcone hybrid compounds have been synthesized in good- to-excellent yields using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester to afford 3-acetylcoumarine and the product has been treated with an aromatic aldehyde using L-proline as a bioorganic catalyst to yield 1-(3̒-coumarinyl)-3-aryl-2-propen-1- one (3-cinnamoylcoumarins)

Key words: 3-Acetylcoumarine, salicylaldehyde, ethyl amine, L-proline, chalcone.






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