|ECB. 2019; 8(10): 335-338
CONDENSATION REACTION BETWEEN 3- ACETYLCOUMARINE AND ARYL ALDEHYDES IN THE PRESENCE OF L-PROLINE
Malihe Kamalpour, Farahnaz. K. Behbahani.
3-Acetylcoumarine and a series a coumarin-chalcone hybrid compounds have been synthesized in good- to-excellent yields using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester to afford 3-acetylcoumarine and the product has been treated with an aromatic aldehyde using L-proline as a bioorganic catalyst to yield 1-(3̒-coumarinyl)-3-aryl-2-propen-1- one (3-cinnamoylcoumarins)
Key words: 3-Acetylcoumarine, salicylaldehyde, ethyl amine, L-proline, chalcone.