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Correlation of thrombocytopenia in urban childern with malaria

Gurudutt Joshi, Nilay Chaudhary, Yogesh Labana, Vimal Tailor.




Abstract

Background: Malaria, is endemic in Surat, (an industrious city of Gujarat), which is categorised under High risk zone. Malaria affects all blood components and is a true haematological disease. Thrombocytopenia and anaemia are the most frequently malaria associated haematological complications of malaria.

Aims & Objective: To study the occurrence, severity and correlation of Thrombocytopenia in urban children with malaria.

Materials and Methods: A retrospective study was conducted at Surat Municipal Institute Of Medical Education and Research (SMIMER) , Surat Gujarat . The Data of all smear positive and Rapid Diagnostic Test positive malaria cases of age between 1 and 17 year admitted in the Deptt. Of Pediatrics were collected. These patients were further assessed for thrombocytopenia, its severity, its relation with type of malaria and age.

Results: Thrombocytopenia was observed in 233 (74%) cases of Malaria of which P. vivax was in 103 (44%) cases, P. falciparum in 130(56%) cases. Severe thrombocytopenia was observed in 22% and 29% cases of Pv and Pf malaria respectively. Sensitivity of thrombocytopenia in Pv and Pf was 71.53% and 76.92% whereas specificity was 66.67 for both respectively. Sensitivity of thrombocytopenia in Pv increased as the platelet count decreased.

Conclusion: Thrombocytopenia is a frequent overall manifestation of both falciparum and Vivax malaria Severe Thrombocytopenia should alert one to consider a possibility of malaria in children.

Key words: Thrombocytopenia , Plasmodium vivax (Pv), Plasmodium falciparum(Pf) ,Severe malaria






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