Soybean and Canola oil are widely consumed cooking oils all over the world. Oils and fats are harmful to health so the experiment was conducted to study the possible histo-toxicological impacts of long term dietary supplementation of Soybean and Canola oil on liver in Swiss albino mice. A total of 30 male Swiss albino mice at 6 weeks old were used in the study and inconstantly prorated into 5 equivalent groups as group A was considered as control, group B1 (25ml so/kg pellet) and B2 (35ml so/kg pellet) were supplemented with Soybean oil (so) and group C1 (25ml co/kg pellet) and C2 (35ml co/kg pellet) supplemented with Canola oil (co) respectively in addition to pellet for 60 days. After completion of study period samples (blood and liver) were collected from the mice of each group and the biochemical, gross and histopathological study was performed. The biochemical study revealed that ALT and AST values were increased significantly in Soybean and Canola oil supplemented groups comparing that of the control group. Gross study revealed that significantly higher liver weight was found in Soybean and Canola oil supplemented groups of mice than the control group. Histopathological study revealed that congested portal vein and dilated bile duct was found in the liver of Soybean oil supplemented groups of mice. There was a congested portal vein was found in the liver of Canola oil supplemented groups of mice. From the present experiment, it could be concluded that Soybean and Canola oil have histo-toxicological effects on the liver of mice.
Key words: Soybean oil, Canola oil, biochemical, gross, histopathology, mice.
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