The actinic cheilitis (AC) can be defined as clinical and histological changes induced by sun exposure. It often develops on lower lip in middle-aged people and may turn to squamous cell cancer (SCC) into long-term period. The biopsy is essential for diagnose and treatment. In this case 37 years old female patient applied to dermatologist about two years ago because of the crusty, ulcerated lesion on the lower lip is presented. AC had been diagnosed with biopsy and cryotheraphy had been applied twice at intervals. After a rapid growing period of lesion the patient had consulted to plastic surgery clinic. Simple vermilionectomy had been performed and squamous cell carcinoma was reported as pathologically. She followed up for 24 months and determined any evidence of recurrence or metastasis.
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