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Original Article



Restoration of pro-inflammatory cytokines and histopathological changes in pancreas and liver of hyperglycemic rats by Murraya koenigii leaves extract

Fauzul Husna, Franciscus D. Suyatna, Wawaimuli Arozal, Erni H. Purwaningsih, Yulvian Sani.

Abstract
The present study aims to investigate whether anti-inflammatory properties and hepato-pancreas protective effect mediate the antihyperglycemic effect of Murraya koenigii. Twenty five Spraque-Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The hyperglycemic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w). After the administration of Murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Blood and organ samples were collected under a fasting condition. The rats were evaluated the expression of pro-inflammatory cytokines (TNF-α, IL-1β) and histopathological changed in liver and pancreas. The beneficial effects of Murraya koenigii accompanied by the anti-inflammatory and hepatoprotective effect of Murraya koenigii and increased the number and size of islet Langerhans. The present study reveals that Murraya koenigii possesses anti-inflammatory, hepatoprotective, and promote the regeneration of damaged pancreatic islet. This effect is accompanied by a decrease in plasma glucose levels.

Key words: Anti-inflammatory, histomorphological, hyperglycemia, Murraya koenigii



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