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Review Article

SRP. 2021; 12(1): 1212-1218


Nanosuspension As An Innovative Nanotechnology Trend Drug Delivery System: A Review

Mustafa R. Abdulbaqi, Hassanien S. Taghi, Zahraa M. Jaafar.

Abstract
Solubility, the freedom of the drug from its route of administration, is the key factor for drug efficacy. Most of recently discovered drugs are insoluble in water and hence poorly absorbed with reduced bioavailability that lead to more production efforts. Due to their flexible characteristics and specific advantages, nanosuspensions has introduced as promising technique for effective hydrophilic drugs delivery. The reduction into the submicron range of drug particles leads to a major increase in rate dissolution and thus improves bioavailability of the drug. Nanosuspension involves colloidal dispersed submicron particles of the pharmaceutical active drug ingredient in liquid-phase stabilized with a surfactant. By oral and non-oral route of administration, nanosuspensions can be administered. Study focuses on different preparation methods with advantages and disadvantages, characterization techniques, and implementations.

Key words: Nanosuspension, Particle Size Reduction, Solubility Improvement, Bioavailability enhancement.



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