The current study was planned to investigate the hepatoprotective effect of curcumin (Cr) against oxidative stress insults characteristic for hepatitis induced by Fluvastatin (F) in female rats. Animals were divided into Three groups: group1 (negative control), group2 (F-control), group3 (F+Cr). Rats were received F for first 10 days while received Cr for all 20 days (duration of experimental period). Results obtained showed that F significantly increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AlP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, malondialdehyde (MDA), tumor necrosis factor α protein (TNFα), tumor growth factorβ1 (TGFβ1), nuclear factor Kappa B (NFKB), cyclooxygenase-1 and 2 (COX-1 and 2), while, decreased the levels of albumin and total protein, reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase (CAT) and interleukin-10 protein (IL-10). Liver histological and immune-histochemical investigations of rats administered F showed sever congestion in portal vein associated with fibrosis and inflammatory cells infiltration. Also, collagen-I stained cells were found in the portal area and the central vein. On the other hand, animals treated with curcumin showed improvements for these parameters as well as in the histological and immune-histochemical feature of the liver. Therefore, the present results indicated that curcumin could reduce oxidative stress and inflammation characterizing hepatitis.
Key words: Fluvastatin, Curcumin, Hepatitis, Oxidative stress, Rats.
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