Home|Journals|Articles by Year|Audio Abstracts RSS - TOC

Original Research

RMJ. 2019; 44(2): 259-262

Intensification of the nephrotoxicity caused by colistin with concurrent use of captopril

Zarafshan Bader, Wardha Mazhar Malik, Imrana Maqsood Khan.


Objective: The simultaneous use of colistin and captopril was studied to find the effect on renal function.
Methodology: The study was performed at Department of Pharmacology & Therapeutics, Army Medical College, Rawalpindi, Pakistan. Colistin was given as intravenous infusion followed by intra-muscular injections to rabbits for six days in two different doses as low and high toxic groups. Captopril was given orally alone and in combination with the low and high toxic dose. Serum urea, creatinine, sodium and potassium were recorded and histopathological studies of kidneys done.
Results: All the serum markers of renal functions were escalated. The histopathology showed grade 2 and grade 3 nephrotoxicity.
Conclusion: Patients with serious infections undergoing treatment with colistin must not be given captopril, as the nephrotoxicity is potentiated with this combination even when the dose of colistin is less.

Key words: Colistin, colistin methane sulphonate sodium, captopril, nephrotoxicity.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com
• ojshosting.net

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.