Abstract

An atom efficient synthesis of polysubstituted dihydropyridine derivatives was accomplished by the one-pot four-component condensation
of aldehydes, amines, dialkyl acetylene dicarboxylates and active methylene group-containing compounds such as malononitrile or ethyl
cyanoacetate using morpholine as a catalyst at ambient temperature. Broad substrate scope, non-chromatographic purification, good yields
of the products makes it be a useful and valuable methodology for employing the 1,4-dipolar intermediates in synthetic organic chemistry.
Use of organobase as a single catalyst, room temperature conditions renders the method protocol as a significant addition to the existing
methods for the synthesis of multifunctionalized dihydropyridines.

Key words: One pot; multicomponent; dihydropyridines; morpholine.