This study sought to investigate the prevalence of colistin-resistant Gram-negative bacteria (CoR-GNB) among P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae isolated from patients with bacteremia and to identify other antimicrobials as a potential therapy for CoR-GNB infections. We retrospectively reviewed the data of non-repeated clinical bacterial isolates from patients admitted to Phramongkutklao Hospital during May 2017 to April 2018. We obtained the minimum inhibitory concentrations (MICs) of the studied isolates and interpreted the MIC values followed by the Clinical Laboratory Standards Institute (CLSI) criteria. Out of 623 bacterial isolates, the prevalence of E. coli was predominantly high (349), followed by K. pneumoniae (150), P. aeruginosa (64), and A. baumannii (60). The CoR-GNB rates among E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa were 2.9%, 17.3%, 5.0%, and 1.6%, respectively. Seven out of 26 colistin-resistant K. pneumoniae isolates and seven out of 10 colistin-resistant E. coli isolates were still susceptible to carbapenems (the MICs for imipenem and meropenem were
Key words: Antimicrobial susceptibility, Colistin, Minimum inhibitory concentration, polymyxins, Gram-negative bacteria
|
