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Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects

V Shanmugapriya, PK Mohanty, D Anil Kumar.




Abstract

Background: Thyroid hormones plays an important role in control of metabolism in human. Hyperlipidaemia particularly hypercholesterolemia, is a well-documented significant health consequence associated with hypo-thyroidism. Oxidative stress is a common factor associated with several clinical conditions including hypothyroidism.

Aims & Objective: To evaluate the association between BMI, Hyperlipidaemia, Lipid Peroxidation and Atherogenic risk in newly diagnosed hypothyroid patients.

Material and Methods: 85 newly diagnosed hypothyroid cases and 41 euthyroid controls were studied for their Thyroid profile [TSH, T4 andT3], Lipid profile , Oxidative stress marker, Malondialdehyde {MDA} Lipid risk ratios, [TC/HDL-C and LDL-C / HDL-C ratio] , Atherogenic index [AIP] - log TG/HDL-C and Body Mass Index [BMI].

Results: Hypothyroid patients had hyperlipidaemia, especially hypercholesterolemia [224 ± 43.8 mg/dl], increased LDL-C level [150.4 ± 42.3 mg/dl] when compared to controls [169.5 ± 25.1 and 97 ± 25.5 respectively]. MDA was significantly increased [p< 0.0001] in hypothyroid subjects [6.14± 1.83μ mol/L] versus the controls [2.9 ± 0.86 μmol/L] .BMI had positive correlation with TSH [r =4.421; p

Key words: Hypothyroidism; Body Mass Index (BMI); Thyroid Stimulating Hormone (TSH); Atherogenic Index






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