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Review Article

SRP. 2021; 12(2): 500-505

Anticancer Effect of Green Synthesized Gold Nanoparticles Using Orchid Extract and their Characterizations on Breast Cancer AMJ-13 Cell Line.

Rana M. Yas, Dhelal Abdul Ghafoor, Muna Ahmed Saeed.

Gold nanoparticles (AuNPs) have shown numerous unique characteristics, such as biocompatibility, and are an excellent factor for biological applications. In this work,Gold nanoparticle green synthesis was tested using orchid plant extract, and their efficacy against EMJ cells was evaluated in vitro breast cancer.The synthesized AuNPs were described by UV-Vis (UV-Vis spectrophotometer), FTIR (Fourier Transform Infrared Spectroscopy), and AFM(atomic power microscopy) TEM (transmission electron microscopy). The absorbent gold nanoparticles in the UV spectrum were 528 nm. Sphere morphology for synthesized AuNPs ranging in size from 14 to 50 nm was shown for the AFM and TEM analyses. The cytotoxicity of AuNPs was measured with MTT testing on breast cancer cell lines. Selected gold nanoparticles have different concentrations (,25,50,100) μg / ml. The inhibition rate of cancer cells depends on the AuNPs concentration, as the concentration increase the percent of inhibition increase. The results confirmed the strong anti-cancer agent of green synthesized AuNPs, which is promising for biomedical applications.

Key words: green synthesis, gold nanoparticles, orchid plant, anti-cancer.

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