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Original Article

Ulutas Med J. 2019; 5(3): 175-183

Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran

Saeedeh TarvijEslami, Hosain Nasirian, Arezoo Sadat Razavi, Hamid Zaferani Arani, Mahshid Dareh, Poorya Bikarannejad, Yasamin Zivari, Maryam Sadat Motevalli, Seyed Amirhossein Ahmadi, Elnaz Babakhani.


Background: The promotion of breastfeeding is a simple and efficient strategy in reducing morbidity and mortality among newborns worldwide. Domperidone is a blocker of dopamine receptors, which causes prolactin release. We aimed to determine the efficacy of Domperidone on the amount of breast milk secretion among mothers with low-milk-production.
Materials and Methods: This interventional study was performed on 16 consecutive low-milk-producing women who were attending to Azad University Hospitals during 2013-2014. Eligible mothers received Domperidone at a dose of 30 mg orally/day (10 mg tablet three times daily) for a week. Breast-milk volume, as well as the serum levels of prolactin, were determined before and after the intervention. Also, any adverse drug reactions were recorded.
Results: The mean breast milk volume was 173.7±47.7 and 326.8±26.1 ml before and after the intervention, respectively. Also, administered of Domperidone cloud significantly increase of %53.1 (p

Key words: Breast Feeding, Domperidone, Efficacy, Side Effects

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