Home|Journals|Articles by Year|Audio Abstracts
 

Research Article

ECB. 2019; 8(1): 26-30


SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED 2-PHENOXYNICOTINALDEHYDES AS α-AMYLASE INHIBITORS

Ravibhushan S. Kulkarni, Nitin B. Haval, Jeetendra A. Kulkarni, Prashant P. Dixit, Kishan P. Haval.




Abstract

Diabetes mellitus is a chronic endocrine disorder that affects the metabolism of carbohydrates, proteins, fat, electrolytes and water. α- Amylase and α-glucosidase are the crucial enzymes required for the digestion of the carbohydrate. These enzymes play a vital role in the breakdown of starch in the diet and its activity has been correlated to postprandial blood glucose levels, the control of which is essential for maintaining the quality of life for diabetic patients. We report the synthesis, characterization and biological evaluation of new substituted 2- phenoxynicotinaldehydes as α-amylase inhibitors. A new general method based on the aromatic nucleophilic substitution reactions of 2- chloronicotinaldehyde with differently substituted phenols in the presence of K2CO3 in dry dioxane was developed to furnish the corresponding substituted 2-phenoxynicontinaldehydes with 70-80% yields.

Key words: diabetes; α-amylase; α-glucosidase; 2-phenoxynicotinaldehydes.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.