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Research Article

ECB. 2019; 8(1): 1-6


SYNTHESIS AND ANTICANCER EVALUATION OF NEW BENZENESULFONAMIDE DERIVATIVES

Rohini N. Shelke, Dattatraya N. Pansare, Chandraknat D. Pawar, Mininath C. Khade, Vrushali N. Jadhav, Satish U. Deshmukh, Ajit K. Dhas, Pravin N. Chavan, Aniket P. Sarkate, Rajendra P. Pawar, Devanand B. Shinde, Shankar R. Thopate.



Abstract
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A highly efficient protocol was developed for the synthesis of 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide compounds with
excellent yields. The in vitro anticancer activity of the new 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide derivatives against
A549 (lung cancer cell), HeLa (cervical), MCF-7 (breast cancer cell) and Du-145 (prostate cancer cell) cell lines were studied. Most of the
tested compounds showed anticancer activity (IC50 values ranged between 1.98 and 9.12 µM against different cell lines).

Key words: Ind‾ sulfonamides; anticancer activity





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070809101112010203040506
20252026

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