Home|Journals|Articles by Year|Audio Abstracts
 

Research Article

ECB. 2020; 9(1): 10-21


PYRIDINE AND BENZOISOTHIAZOLE BASED PYRAZOLINES: SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY, MOLECULAR DOCKING AND ADMET STUDY

Pintu G. Pathare, Sunil U. Tekale, Manoj G. Damale, Jaiprakash N. Sangshetti, Rafique U. Shaikh, László Kótai, Rajendra P. Pawar.




Abstract

Synthesis, characterization, antioxidant and antimicrobial activities of novel pyrazolines and phenylpyrazoline containing substituted pyridine and piperazine benzoisothiazole moieties have been reported. When these synthesized compounds were exposed for antioxidant screening, some among them exhibited prominent DPPH radical scavenging activity and superoxide radical (SOR) scavenging activity where ascorbic acid used as standard. During the antimicrobial screening compounds, some derivatives were found to be very active against Cryptococcus neoformans, which was supported on the basis of higher free binding energies with methionyl-tRNA synthetase.

Key words: Pyrazolines; antioxidant; antimicrobial; molecular docking.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.