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Research Article

ECB. 2018; 7(11): 324-328


ONE-POT GREEN SYNTHESIS OF 3-AMINO-1-(5-NITRO-1HINDOL-2-YL)-5,10-DIOXO-5,10-DIHYDRO-1H-PYRAZOLO[1,2- b]PHTHALAZINE-2-CARBONITRILE AND RELATED COMPOUNDS

Rama Koteshwar Rao, Shravankumar Kankala.




Abstract

Synthesis of 3-amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-2-carbonitriles by a one-pot green and an eco-friendly reaction of phthalic acid, hydrazine hydrate, indole-3-carboxaldehydes and malononitrile/ethyl cyanoacetate in the presence of Et3N as catalyst and Glycerol mediated at 100-105 oC for 45-60 min. This one-pot reaction proceeded in a short time with good yields and the desired products obtained without using column purifications.

Key words: Eco-friendly synthesis; One-pot reaction; pyrazolo[1,2-b]phthalazine; glycerol; triethylamine catalyst.






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