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Research Article

ECB. 2018; 7(8): 218-222


FORMULATION AND EVALUATION OF NANOSUSPENSIONS OF TADALAFIL USING DIFFERENT STABILIZERS

Haritha Meda, G. Devala Rao, V. Harini Chowdary, MandavaBhuvan Tej.




Abstract

In the present study, an attempt was made to prepare oral nanosuspension of Tadalafil. Tadalafil is a PDE5 inhibitor used for treating erectile dysfunction (ED) and pulmonary arterial hypertension. Tadalafil nanosuspensions were prepared by nanoprecipitation method using different polymers (such as sodium lauryl sulphate (SLS), TWEEN-80, TWEEN-20, Pluronic F127) and acetone. Estimation of Tadalafil was carried out spectrophotometrically at 285nm. The oral nanosuspension were evaluated for various physical and biological parameters, drug content uniformity, particle size analysis, zeta potential, invitro drug release, short-term stability, drug-excipient interactions (FTIR). Out of the formulation from F1 to F12, F11 containing TWEEN-20 (0.3 %) showed 99.74 % release at the end of 30min and follows first order drug release kinetics.

Key words: Tadalafil; oral nano suspension; sodium lauryl sulphate; Tween-20; Pluronic F127; Tween-80;






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