Secondary amyloidosis is a consequence of chronic inflammatory diseases that results in deposition of amyloid in organs disrupting its function. Oral involvement with this process is exceedingly rare.
A 63-year-old Pakistani female with a history of rheumatoid arthritis and ankylosing spondylitis was seen in the Oral Medicine Clinics for painful oral nodules that were diagnosed as AA-type, or secondary amyloidosis, following an incisional biopsy. Similar deposits were identified in vital organs on subsequent examination by the patientís physicians. Due to widespread systemic involvement, our patient died within 6-months of her diagnosis.
This case serves as a reminder that oral presentations may be the first identifiable signs of systemic diseases. It also emphasizes the importance of multidisciplinary clinical practice, and the lack of it in our country.
AA amyloidosis, secondary amyloidosis, oral amyloidosis