Home|Journals|Articles by Year|Audio Abstracts

Original Article

Attenuation of cisplatin-induced hepatotoxicity by nanocurcumin through modulation of antioxidative and anti-inflammatory pathways

Melva Louisa, Azis M Putera, Antasena A. Sidqi, Dimas Kirana Mahaputra, Ekida R. Firmansyah, Muhammad F. Ammar, Natasha Talya, Ni Nyoman Berlian Aryadevi, Ni Made Dwi Sandhiutami, Dewi Sukmawati, Vivian Soetikno.

Cited by 2 Articles

The present study aimed to investigate whether curcumin in nanoparticle form may provide hepatoprotection in an ovarian cancer model in rats treated with cisplatin. Twenty-five female Wistar rats were divided into five 4-week treatment groups: (1) healthy rat group and four groups of 7,12-dimethylbenz(a)anthracene-induced ovarian cancer model rats receiving (2) vehicle only, (3) cisplatin 4 mg/kg BW/week, (4) cisplatin 4 mg/kg BW/week + curcumin 100 mg/kg BW/day, and (5) cisplatin 4 mg/kg BW/week + nanocurcumin (NC) 100 mg/kg BW/day. At the end of the treatment, a histopathological evaluation was carried out on the liver samples, in addition to oxidative stress, apoptosis, inflammatory, and fibrosis markers analyses. The group treated with cisplatin + NC had lower aspartate transaminase and alanine transaminase levels and lowered malondialdehyde and higher glutathione levels than those treated with cisplatin only. In addition, the nuclear factor-erythroid factor 2-related factor 2/Kelch-like ECH-associated protein 1 pathway genes were upregulated in the group treated with cisplatin + NC. We also demonstrated that NC effectively suppressed the gene expression of inflammatory marker tumor necrosis factor-α, as well as fibrosis marker transforming growth factor-β1. Furthermore, NC treatment reduced the fibrotic area in the hepatic tissues, as shown by Masson’s trichrome staining. In conclusion, the hepatoprotective effects of NC are mediated through the modulation of antioxidative and anti-inflammatory pathways.

Key words: cisplatin, curcumin, hepatotoxicity, nanoparticles, oxidative stress, turmeric.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.