Home|Journals|Articles by Year

Directory for Medical Articles
 

Review Article



NIBRIN DOUBLE STRAND BREAKAGE AND ITS ROLE IN DEVELOPMENT OF CANCERS

fizza abidi,Mervyn Hossein,saima akram,angbeen anjum.


Abstract

ABSTRACT:
The human genetic information has been orchestrated by DNA-damage response pathways.DNA damage response, DNA repair, programmed apoptosis and cell cycle progression are responsible for maintaining the genomic integrity, they initiate the process of tumorigenesis if they are not regulated properly. The review aims is to point out the impact of double-strand breakage and the role of Nibrin in development of cancers. The double-strand breakage are pathological insults for all the microorganisms because they can cause the elimination of the essential genetic information, which destroys DNA replication Nibrin is the DNA repair gene whose overexpression can promote the process of tumorigenesis by the activation of phosphoinositol 3 kinase /akt pathways.

Key words: Nibrin, Double strand breakage, P95 ,NBS1






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.