The human genetic information has been orchestrated by DNA-damage response pathways.DNA damage response, DNA repair, programmed apoptosis and cell cycle progression are responsible for maintaining the genomic integrity, they initiate the process of tumorigenesis if they are not regulated properly. The review aims is to point out the impact of double-strand breakage and the role of Nibrin in development of cancers. The double-strand breakage are pathological insults for all the microorganisms because they can cause the elimination of the essential genetic information, which destroys DNA replication Nibrin is the DNA repair gene whose overexpression can promote the process of tumorigenesis by the activation of phosphoinositol 3 kinase /akt pathways.
Nibrin, Double strand breakage, P95 ,NBS1
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Santos-Ortega Y, Flynt A
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Garbatti Factor B, de Moura Manoel Bento F, Figueira A
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