Abstract

Background: Diabetes mellitus is a heterogeneous disorder that affects cellular metabolism in variety of ways and coagulation indices are reported to be adversely affected.Insulin resistance is a marked pathophysiology of Type II diabetes causing abnormalities in the microvascular and macrovascular circulations. The entire coagulation cascade is dysfunctional in such condition. Platelets may assume an important role in atherosclerosis in diabetes. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are haematological indices that give an idea about the coagulation status of patients. Hence the present study is undertaken to see the effect of diabetes on platelet aggregation and coagulation parameters like PT and APTT.

Aims & Objective: To study platelet aggregation and clotting time (PT, APTT) in type II diabetic males.

Materials and Methods: The present study included 30 type II diabetic males and 30 normal male subjects. Platelet aggregation was studied by O Brein J R method using ADP reagent. Clotting time (prothrombin time, activated partial thromboplastin time) was estimated by using coagulometer.

Results: ADP induced platelet aggregation was significantly higher while PT and APTT were significantly lower in diabetic group compared with control group (p

Key words: Diabetes Mellitus; Platelet Aggregation; Prothrombin Time (PT); Activated Partial Thromboplastin Time (APTT); Insulin