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Research Article

JCDR. 2021; 12(3): 3012-3023


IN –SILICO DESIGN OF EPITOPE BASED PEPTIDE VACCINE AGAINST BARMAH FOREST VIRUS THROUGH IMMUNE-INFORMATIC APPROACH

Melike Sravani,M.Lakshmi Durga,B.Suranjan,Bala Yaswanth Kumar.S,A.Deekshit, Kanaka Durga Devi.N*.


Abstract

BFV mainly causes the poly arthritis, occurs in between the ages of 20 to 60. Currently there is no vaccine or drugs for the treatment. We describe an In-silico multi epitope vaccine targeting BFV membrane glycoproteins and predict B and T cell epitopes for immunogenicity, allergenicity, toxicity and conservancy. Epitopes were screened by docking with HLA alleles to generate highest immune response. The 3D structure of the vaccine was determined. Results need to be supported in – vitro and in- vivo for efficacy and safety.

Key words: BFV, Multi Epitope Vaccine, Glyco Protein, Immuno Informatics, Vaccine Design.






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