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The Effect of Gentamicin on the Action of Atracurium in Adult Patients

Walid A.A. Abdeltawab, Mohamed E.A. Abdelrahim, Amira S.A. Said, Ahmed A. Ahmed, Mahmoud A. Nassef.

The aim of the trial was to study the effect of Gentamicin as an aminoglycoside on Atracurium as a neuromuscular blocker. Forty patients (20-60 years old) who had minor surgical procedures were enrolled in the study. All the patients were with the American Society of Anaesthesiologists (ASA) physical status I-II with elective surgery in supine position. Patients were represented to full history, clinical examination and laboratory tests at Beni suef University Hospital to be sure that they met the criteria. Patients were divided into two equal groups. Group I (Atracurium-Gentamicin) and Group II (Atracurium alone). Group I received Gentamicin at dose of 2 mg/kg 5 minutes before starting the general anesthesia. The degree of muscle relaxation was monitored by using peripheral nerve stimulator with recording of Train of Four (TOF) ratio every 10 minutes. Clinical duration, onset time, time to spontaneous recovery T4/T1 ratio and occurrence of recurrence of the neuromuscular blockade were assessed. At the end of anesthesia it was noticed that there was no significant difference according to onset time, clinical duration or time to spontaneous recovery. Hence, there was no effect of using Gentamicin preoperatively on the action of the Atracurium.

Key words: Gentamicin, atracutium, neuromuscular blocker

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