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SRP. 2021; 12(1): 726-732

The Levels of Acrylamide and Glycidamide as Biomarker in Smokers: An Article Review

Yahdiana Harahap, Anastasia Sharon Jautan, Sunarsih.


Cigarette smoke is the major source of acrylamide exposure after food. Acrylamide is classified as a probable carcinogenic to humans. Acrylamide is metabolized by CYP2E1 into glycidamide that is very reactive to DNA and can form DNA adducts causing carcinogenic effects in humans. Acrylamide levels in cigarette smoke is around 1.000–7.991 µg/cigarette. Acrylamide exposure in smokers is 2.2–4.6 times higher than non-smokers and glycidamide exposure 1.1–3.8 times higher than non-smokers. Acrylamide and glycidamide are found in blood, body tissues, placenta, and breast milk. The levels of acrylamide and glycidamide in Dried Blood Spot (DBS) sample are still unknown. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) can be used to quantify small amounts of analytes. Volumetric application or microfluidic DBS used to overcome hematocrit effect.

Key words: Acrylamide, Glycidamide, Smoker, Dried Blood Spot, LC-MS/MS

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