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Research Article

JCDR. 2022; 13(1): 476-482

Association of Disease Activity with Vitamin D in Early Rheumatoid Arthritis

Kumar Manoj, Yadav Shushil Kumar, Ahirwar Shashi, Ahmed Saleem.


Objective: Aim of the present study is to find out the level of vitamin D in patients of early rheumatoid
arthritis and investigate association of vitamin D deficiency with the disease activity in rheumatoid
Methods: A case control study comprising 90 case of early rheumatoid arthritis and 80 age and sex
matched control carried out at tertiary care hospital in western province of Uttar Pradesh India between
January 2017 and June 2021. Baseline data along with vitamin D level was recorded in both the group.
Disease activity was recorded using clinical disease activity index (CDAI) in all patients of rheumatoid
Results: Vitamin D deficiency was significantly higher in rheumatoid arthritis patients compared to
healthy control from same geographic region (56.7% vs 32.5%, p value = 0.002%). Disease activity
assessed by clinical disease severity index (CDAI) was inversely correlated with vitamin D level(r= -0.23,
p-value 0.028) and. Joint pain was also inversely correlated with vitamin d level(r= -0.37, p value

Key words: vitamin D, rheumatoid, arthritis, CDAI , joint, tenderness

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