Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Hemolytic and DNA nicking studies of anti-cancer peptide

Jagatheesh Kaliaperumal, Kowsalya Rangasamy, Parvathavarthini P,Pavankumar Padarthi, Elangovan Namasivayam.

Background: In recent years studying of in vitro toxicity encompass their possess significance to proceed any compound to further pharmaceutical procedure. In this we taken peptide which is supposed to be bind with DNA to produce anti-cancer possessions so it requires studying for its genotoxic possessions.

Aims & Objective: To study Hemolytic and DNA nicking of anti-cancer peptide.

Materials and Methods: Simple agarose gel was used to electrophoresis to determine the DNA nicking property and hemolytic assay also performed to ensure the safety of the peptide in biological system.

Results: It was found that peptide is being safe even at elevated concentration 40 ng which cannot be achieved in biological distribution and the hemolytic assay shows the IC50 value 25.24 μg/ml which is also an awfully higher concentration in in vivo terms.

Conclusion: It is concluded the peptide have safe use in biological system.

Key words: Peptide; Electrophoresis; DNA Nicking; Haemolytic Assay

Full-text options

Full-text Article

Applied Medical Research


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.