The objective of this study was to investigate the effect of Goldenberry (GB) (Physalis peruviana) extract supplementation on fat accumulation, hepatic oxidative damage, hepatic fat deposition, inflammation, and hepatic scarring as well as metabolic syndrome in obese rats. Obesity was induced by feeding rats a high-fat diet (HFD) for 12 weeks. Female Wister rats were divided into four groups: control group, obese group, obese + a low dose GB (200 mg/kg), and obese + a high dose GB (400 mg/kg). Body mass index (BMI), adipose tissue hormones, lipid profile, liver enzymes, hepatic oxidative stress parameters, and hepatic histopathological changes were assessed. Treating obese rats with GB supplementation reduced their increased body weight, BMI, leptin level, cholesterol, triglycerides, glucose, and insulin resistance index (HOMA-IR). Moreover, the GB regime significantly improved the antioxidant parameters in the liver; in addition, it has shown a significant anti-obesity impact by lessening body weight, oxidative damage, BMI, lipids, and insulin insensitivity. Eventually, administration of GB extracts reduced markers of inflammation (TNF-α, IL-2, IL-6, and CRP), fat deposition, steatosis, and fibrosis in the liver of the obese rats. Moreover, GB intake can be used in coupling with a healthy diet to assist obese rats suffering from metabolic syndrome.
Key words: Obesity, Goldenberry, Inflammation markers, Oxidative stress, Metabolic syndrome, Liver pathology
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