Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode.

Cited by (3)

Background: Cardiovascular Autonomic Diabetic Neuropathy (CADN) is one of the most important diabetes- associated complications. Reduced heart rate variation (HRV) is the earliest indicator of CADN. The prospect of using time domain analysis of HRV using mental arithmetic as a stressor has for early diagnosis of CADN has not been studied so far.

Aims & Objective: To compare time domain parameters of HRV at rest and during acute mental stress between Type 2 diabetics and non- diabetics.

Materials and Methods: 30 male asymptomatic, Type 2 diabetics with duration of diabetes of 2-8 yrs with RBS ≥ 200 mg/dl or FBS ≥ 126 mg/dl in the age group of 30-65 yrs were chosen as subjects. 30 age and sex matched healthy non-diabetics were chosen as controls. HRV analysis was done using ECG recorded at rest in supine position for 5 min and during 5 min of acute mental stress testing.

Results: At rest standard deviation of all R-R intervals (SDNN), root mean square of successive RR- interval differences (RMSSD), number of intervals differing by > 50ms from adjacent interval (NN50) and percentage of NN50 (pNN50) were significantly less in diabetics as compared to non- diabetics. Mental stress showed increases in HR, SBP and DBP in non-diabetics as well as diabetics but SDNN was significantly less in diabetics as compared to non- diabetics during stress.

Conclusion: Data from the study demonstrated that diabetics with 8-10 yrs history had already developed parasympathetic autonomic neuropathy. Time domain analysis of HRV during mental stress can be used as a valuable tool for early diagnosis of autonomic neuropathy to prevent further complications.

Key words: Heart rate variability, Time Domain Analysis, Cardiovascular Diabetic Autonomic Neuropathy

Similar Articles

Multiclass cyanotoxin analysis in reservoir waters: Tandem solid-phase extraction followed by zwitterionic hydrophilic interaction liquid chromatography-mass spectrometry.
Aparicio-Muriana MM, Carmona-Molero R, Lara FJ, García-Campaña AM, Del Olmo-Iruela M
Talanta. 2022; 237(): 122929

Analysis of Commitment Point Attainment in Algae Dividing by Multiple Fission.
Kselíková V, Zachleder V, Bišová K
Methods in molecular biology (Clifton, N.J.). 2022; 2382(): 89-101

A Protocol for Genome-Wide Analysis of DNA Replication Timing in Intact Root Tips.
Mickelson-Young L, Wear EE, Song J, Zynda GJ, Hanley-Bowdoin L, Thompson WF
Methods in molecular biology (Clifton, N.J.). 2022; 2382(): 29-72

Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions.
Huang P, Zhao Z, Duan L
Neural regeneration research. 2022; 17(1): 25-30

Exosome treatment for stroke with diabetic comorbidity.
Venkat P, Chopp M
Neural regeneration research. 2022; 17(2): 315-317

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites