Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Effect of premedication on side effect frequency in patients to whom immunotherapy is applied

Gulsah Duyuler Aycin, Ayse Senay Sasihuseyinoglu, Derya Ufuk Altintas.




Abstract
Cited by 0 Articles

Aim: In this study we aimed to investigate whether there are differences in terms of the frequency and severity of side effects in patients to whom premedication were given/or not before the application of subcutaneous allergen specific immunotherapy.
Material and method: Patients receiving subcutaneous allergen-specific immunotherapy in our clinic between October 2014 and October 2015 were evaluated for side effects. In patients to whom subcutaneous allergen-specific immunotherapy was applied and reaction was occurred against this therapy; allergen type, reaction intensity and duration, and also use of premedication were recorded. When the patients were assessed in terms of side effects; edema and/or erythema from 2 to 5 cm, which were beginning within the first 24 hours in the injection site. That was defined as ‘local reaction’ and edema and/or erythema, if it was greater than 5 cm defined as ‘broad local reaction’.
Results: Total of 101 patients, to whom allergen specific immunotherapy was applied, were included. In a year of the study; total of 660 injections were applied to 101 patients and reaction to injections were observed in 31 injections (4,6%). Reaction was observed in 20 individuals (19,8%). No significant difference was found between premedicated and non-premedicated groups in terms of the percentage of side effects and risk of side effects (p >0,59).
Conclusion: In our study; patients with or without premedication were compared in terms of side effect frequency. In premedication group; ratio of local reaction was found to be low (20%). It was thought that premedication could reduce local reactions but did not prevent extensive local reaction. There was no difference when comparing the side effect frequency between the two groups.

Key words: Premedication; Immunotherapy; Side Effect.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.