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BTDMJB. 2009; 5(2): 49-53


The effect of dexmedetomidine on propofol amount and hemodynamic parameters at anesthesia induction

Güray Demir, Gülay Eren, Zafer Çukurova, Oya Hergünsel.

Abstract
Objective: In this study, the effect dexmedetomidine usage before anesthesia induction on propofol requirement and hemodynamic changes appearing against laryngoscopy and intubation; and the degree of sedation provided is investigated.
Material and Methods: 80 patients were randomly assigned into two groups (Group DXM, and Group PLS). 30 minutes before induction 1 µg/kg dexmedetomidine in 100ml saline was administered to Group DXM and 100ml saline-only was administered to Group PLS in ten minutes. Anesthesia induction was performed by 2 µg/kg fentanyl, propofol infusion at eyelash reşex; and 0.1 mg/kg vecuronium. Blood pressures and heart rates before premedication, before and after induction, after laryngoscopy and intubation and 5 minutes after intubation and Ramsay scores before and after premedication were evaluated.
Results: While group PLS required 2.27±0.43 mg/kg propofol at induction, this quantity was 1.27±0.22 mg/kg in group DXM (p

Key words: Dexmedetomidine, propofol, induction, sedation



Article Language: Turkish English


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