The effect of perioperatively administered intravenous paracetamol, during caeserean section, on postoperative analgesia and liver function testsDilek Altun, Gülay Aşık Eren, Nalan Saygı Emir, Evrim Kücür, Halil Çetingök, Güray Demir, Zafer Çukurova, Oya Hergünsel.
Objective: In this study, analgesic efficacy of perioperatively administered iv paracetamol during ceaserean section was evaluated together with its effects on liver function tests.
Material and Methods: ASA I-II 75 women scheduled for elective caeserean section (C/S) were randomly assigned into three groups. Following delivery of baby, patients in Group I were given 2 gr; in Group II 1 gr of paracetamol in 15 minutes. Group III patients were taken as control. Postoperative analgesia was achieved by tramadol via patient controlled analgesia (PCA). It was planned to give additional 1 gr of paracetamol doses, if VASâ¥40. Pain scores with VAS, mean arterial pressure (MAP), heart rates (HR), respiratory frequences (RF) were recorded postoperatively at 1,2,3,4,6,8,12 and 24 hours. AST, ALT levels were reevaluated at postoperative 24th hour. Total analgesic required, adverse effects and requirement of antiemetics were recorded.
Results: There was no significant diffrenece between groups regarding pain scores of 24 hours, MAP, RF or transaminases. HR, total required amount of tramadol, frequency of nausea-vomitting were significantly increased in group III ( p
Paracetamol, postoperative analgesia, cesarean, tramadol
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