Abstract

An efficient methodology has been developed by which a series of new 2-indolylmethylene-linked compounds can be readily synthesized by thermal Knoevenagel condensation of 3-methylindole-2-carboxaldehyde and cyclic active methylene compounds under catalyst- and solvent-free conditions.

Key words: Knoevenagel condensation, 3-methylindole-2-aldehyde, cyclic active methylene compounds, catalyst- and solvent-free reaction