An efficient methodology has been developed by which a series of new 2-indolylmethylene-linked compounds can be readily synthesized by thermal Knoevenagel condensation of 3-methylindole-2-carboxaldehyde and cyclic active methylene compounds under catalyst- and solvent-free conditions.
Key words: Knoevenagel condensation, 3-methylindole-2-aldehyde, cyclic active methylene compounds, catalyst- and solvent-free reaction
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