Immunohistochemical Analysis of 1,25-dihydroxyvitamin D3 Receptor Expression in Endometrial Cancer
Abstract
Objective: This study aimed to investigate immunohistochemically the expression of 1,25-dihydroxyvitamin-D3-receptors (VDR).in benign and malignant lesions of the endometrial tissue.
Method: The cases were divided into two groups as benign (n = 10) and endometrioid adenocarcinoma (n = 17) according to their endometrial pathology results. The expression of VDR were examined by immunohistochemical method in endometrial tissues of participants (n=27) then, VDR expression levels were compared between groups. The intensity of expression, staining density and overall scores were determined for the semi-quantitative evaluation of VDR expression. Demographic data of the patients were also recorded.
Results: There was no significant difference between the groups in terms of demographic data (p>0.05) except age (p
Key words: Vitamin D, endometrial cancer, vitamin D receptor
Anahtar Kelimeler: vitamin D, endometriyal kanser, vitamin D reseptörü
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