Background: In the past few years, vitamin D levels have been correlated to multiple medical conditions. Furthermore, it has also been assumed to have protective roles in some situations. However, the antioxidant role of vitamin D is still controversial. This systematic review aimed to provide a holistic overview of vitamin D's antioxidant effects under different medical settings.
Methods: A thorough examination of the medical databases, including OVID, Medline, PubMed, and Embase, was conducted between 2010 and 2020. The keywords used for searching the databases were: vitamin D AND oxidation OR oxidative OR oxidant AND Adult. The outcomes of this search were then refined to include only original research that investigated the antioxidant role of vitamin D in different medical settings. Selected trials included the type of medical setting under investigation.
Result: A total of 93 articles were retrieved. After removing review articles and considering original research articles solely, 12 articles showed up. Eight research articles were to be included. Two studies included healthy adults, two studies included elderly patients; two studies included type 2 diabetes mellitus, one study included ischemic stroke patients. In contrast, one study included non-alcoholic fatty liver disease, diabetic and ischemic stroke patients showed a significant negative correlation between vitamin D levels and oxidative stress, which was controversial among healthy adults.
Conclusion: Vitamin D supplementation can improve the oxidation stress status in multiple pathological conditions. Further studies are required in normal healthy adults.
Key words: Vitamin D, role, deficiency, supplementation, adults, antioxidant.
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