Background. Exposure to magnetic fields (MFs) can affect the release of neurotransmitters, such as acetylcholine, serotonin and dopamine in the brain.
Objective. To study some biochemical changes associated with the exposure to low frequency static and alternating MFs at a flux density of 3 mT.
Methods. Forty male mice were included in this study. Thirty mice were exposed to a combination of static and alternating MFs at a flux density of 3 mT for duration of 1 to 3 weeks. Ten mice were taken as a control group. Activities of acetylcholine esterase (AchE) and monoamine oxidase (MAO) enzymes were determined in whole brain homogenates of these mice.
Results. The activities of both enzymes were significantly increased in mice exposed to the magnetic fields compared to the control group. These changes were more apparent after three weeks of exposure and were associated with some behavioral manifestations. No mortality or body weight changes were reported after MF exposure. In the present study, the enzymatic activities of AchE and MAO-A & -B were found to be significantly increased in brains of mice exposed to low frequency magnetic fields (LFMF).
Conclusion. Exposure to MF causes changes in the activities of brain enzymes and these changes could affect the behavior of the animals exposed to MF.
Key words: Acetylcholinesterase; monoamineoxidase; low frequency magnetic fields; behavioral changes; brain enzymes.
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