Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Case Report

5-fluorouracil-induced manic episode in patients with colon cancer: A case report and literature review

Gulcin Elboga, Perihan Gizem Aksoy, Tulay Kus, Elif Karayagmurlu, Gokmen Aktas, Sengul Sahin, Abdurrahman Altindag.

The combination of 5-fluorouracil (5-FU), irinotecan and bevacizumab (FOLFIRI-beva) is one of the main treatment options for metastatic colon cancer. We present a rare case of irritable mood elevation during FOLFIRI-beva treatment in a man without psychiatric history. A 41-year-old man with colon cancer developed a manic episode after four cycles of chemotherapy. After excluding the other causes, the patient was diagnosed with Medication-induced Bipolar disorder manic episode with mixed features according to the criteria of Diagnostic and Statistical Manual of Mental Disorders, fifth edition. Chemotherapy was discontinued, and antipsychotic treatment with haloperidol and biperidone was started. He recovered after 12 days. While adjustment disorders, depression and delirium are more common in cancer patients, mood disorders are rare during chemotherapy. Neuropsychiatric manifestations are uncommon during 5-FU treatment. Clinicians should keep in mind that a neuropsychological condition or mood disorders may be encountered during chemotherapy especially with 5-FU.

Key words: 5-Fluorouracil; Manic Episode; Mood Disorder; Colon Cancer.

Full-text options

Full-text Article

American Journal of Physiology, Biochemistry and Pharmacology


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.