Water is an essential nutrient so it is important for animals to have an adequate supply of good quality water to maintain satisfactory production. This experiment was carried out to study the effect of drinking varying degrees of natural saline well-water on oxidative stress and histopathological alternation of heart and lung indices of experimental sheep groups in the study area under the arid conditions of southern Sinai. Thirty Barki sheep were allocated into three groups based on the type of drinking water for nine months: the tap water (TW) group, the moderate saline water (MSW) group and the high saline water (HSW) group. Data revealed that, sheep which drinking well water (~5000ppm&~10000ppm) induced in serum samples significant increase of oxidative stress markers (malondialdehyde (MDA) and nitric oxide (NO)) & cortisol and decrease in the values of antioxidants parameters, superoxide dismutase (SOD), total glutathione (GSH), catalase (CAT) and total antioxidant capacity (TAC) compared to sheep drinking tap water. Histopathological examination of lung revealed catarrhal bronchitis and bronchiolitis, hyperplasia of epithelial lining and goblet cell with clear peri bronchial lymphocytic aggregates and edema. Fibrosis, haemorrhagic pneumonia, interstitial pneumonia and abscess formation. On the other hand, heart revealed significant changes in both MSW and HSW groups such as zenker necrosis of muscles, granulation of cytoplasm, slight hemorrhage moderate to severe edema and infiltration of inflammatory cells. In conclusion, water salinity negatively affects oxidative stress and heart & lung appearance of sheep.
key Words: Saline water; Barki sheep, antioxidant enzymes; histopathology; lung, heart, southern Sinai, Egypt
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