Abstract

Diabetes mellitus interferes with the metabolism of carbohydrates, causing chronic hyperglycaemia. Dyslipidaemia in diabetes represents one of the key risk factors for cardiovascular disease. The aim of this study was to evaluate the effect of hydro-alcoholic Prosopis ruscifolia (Pr) leaves extract on hyperglycaemia and lipid profile in normo- and hyperglycaemic mice. Mice hyperglycaemia was induced by alloxan, animals were treated with Pr (50, 100, 200 mg/kg, p.o., 28 days). Fasted blood glucose level on days 7, 14, 21 and 28, was determined. Blood glucose remained within the normal range in the groups of normoglycaemic animals treated with Pr. In the hyperglycaemic animals, 100 mg/kg of Pr extract reduced the glycaemia, this effect became markedly evident since day 7, until the end of experimental period (p

Key words: atherogenic index, coronary risk index, lipids profile, piperidine alkaloid, quercetin