Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research



Vasoactive properties of Ceiba pentandra in porcine coronary artery and different conductance and resistance vessels from rats: A role of nitric oxide

Mbaye Sene, Ibrahima Diouf, Maimouna Toure, Cyril Auger, Catherine Vonthron Senecheau, Mamadou Sarr, Valérie Schini Kerth, Modou Oumy Kane.

Abstract
Background: Ceiba pentandra (L.) Gaertner (Malvaceae) a plant widely spread in the world, particularly in sub-Saharan Africa where it is used to handle several pathologies like high blood pressure without scientific evidence by experimental scientific works.

Aim and Objective: The purpose of this study is to show how a hydroethanolic leaves extract of Ceiba pentandra (FCP) produces relaxant effects in porcine coronary, rat mesenteric artery, carotid, femoral arteries, and thoracic aorta and to determine the mechanisms which lie beneath this effect.

Materials and Methods: Porcine coronary, rat mesenteric, carotid, and femoral arteries and thoracic aorta rings were suspended in organ chambers for recording of changes in isometric forces. Rings with endothelium were incubated or not with L-nitroarginine to block nitric oxide (NO) synthase, manganese (III) tetrakis(1-methyl-4-pyridyl)porphyrin, polyethylene glycol catalase (CAT), an inhibitors of intracellular production reactive oxygen species (ROS); CAT, an inhibitor of extracellular ROS; wortmannin, an inhibitor of redoxsensitive pathway phosphoinositide 3-kinase (PI3 kinase)/Akt; (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo [3,4-d] pyrimidine), an inhibitor of Src kinase; apamin, an inhibitor of small conductance potassium channels calcium dependent (SKCa) and tram-34, an inhibitor of intermediary conductance potassium channels calcium dependent (IKCa); and indomethacin, an inhibitor of cyclooxygenase before contraction with U46619 or phenylephrine and a concentration-relaxation curve to FCP.

Results: Some experiments show that endothelium was taken away before contraction with U46619 and concentration relaxation to FCP. The hydroethanolic leaves extract of C. pentandra produces a vasodilatory result in porcine coronary artery pre-contracted with U46619. This effect is endothelium dependent and is mediated by NO. FCP generates, as well, vasorelaxant results in superior mesenteric arteries, carotid arteries, thoracic aorta, and femoral arteries from rat. C. pentandra generates vascular relaxation which can be the explanation of the benefic effect of this plant in the treatment of high blood pressure (HBP) in Africa.

Conclusion: C. pentandra holds vasorelaxants properties on pig coronary artery, thoracic aorta, the main superior mesenteric artery, and femoral and carotid artery from rat justifying its utilization in the treatment of the arterial HBP. This effect necessitates the presence of a functional endothelium and passes by the redox-sensitive pathway Src kinase and PI3-kinase/Akt.

Key words: Ceiba pentandra; Vasorelaxant Effects; Porcine Coronary; Rat Arteries



Similar Articles

Interrater agreement of contouring of the neurovascular bundles and internal pudendal arteries in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer.
Teunissen FR, Wortel RC, Wessels FJ, Claes A, van de Pol SMG, Rasing MJA, Meijer RP, van Melick HHE, de Boer JCJ, Verkooijen HM, van der Voort van Zyp JRN
Clinical and translational radiation oncology. 2022; 32(): 29-34

In vitro and in silico anti-osteoporosis activities and underlying mechanisms of a fructan, ABW90-1, from Achyranthes bidentate.
Li T, Hou X, Huang Y, Wang C, Chen H, Yan C
Carbohydrate polymers. 2022; 276(): 118730

Effects of selenium-containing compounds on Cu/Zn-induced neuronal cell death and potential application as therapeutic agents for neurological diseases.
Tanaka KI, Shimoda M, Kawahara M
Neural regeneration research. 2022; 17(2): 311-312

Relative power: Explaining the effects of food and cash transfers on allocative behaviour in rural Nepalese households.
Harris-Fry H, Saville NM, Paudel P, Manandhar DS, Cortina-Borja M, Skordis J
Journal of development economics. 2022; 154(): 102784

Effects of a sulfated glycosaminoglycan from Sepia esculenta ink on transcriptional and metabolic profiles of Saccharomyces cerevisiae.
Lin Z, Luo P, Lin X, Chen Y, Zhang Y, Li F, Tan X, Liu H
Carbohydrate polymers. 2022; 276(): 118715


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites