Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. Cardiovascular and renal complications share common risk factors such as blood pressure, blood lipids, and glycemic control. The markers of diabetics nephropathy in diabetic patients, serum glucose, creatinine clearance, urinary albumin and blood pressure in 40 diabetic (9 type I and 31 type II diabetics) patients attending Federal Medical Centre, Gusau, were determined. Sixteen (16) age- matched volunteers served as control. In type I diabetes mellitus; serum glucose level, creatinine clearance, and microalbuminuria were significantly different (P< 0.05) between the subjects and control. In type II diabetes mellitus, serum glucose level, systolic pressure and age were significantly different (P< 0.05) between the subjects and control. Therefore, serum glucose level, creatinine Clearance and microalbuminuria could be the markers of nephropathy in type I diabetics while serum glucose level, systolic pressure and higher age could be for type II diabetics. Other markers of risk for diabetic nephropathy are needed for optimal clinical management. The implication of this result for improving the quality of life of diabetics is discussed.
Key words: Creatinine, Diabetic patients, Glucose, Microalbuminuria.