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Effects of Adding Dexmedetomidine to Amitriptyline on Sciatic Nerve Blockadge in Rats

Mahmut Durmus, Mukadder Sanli, Erdogan Ozturk, Aytac Yucel, Nurcin Gulhas, M. Ozcan Ersoy.




Abstract

Abstract
Neurotoxic effects of amitriptyline which is a tricyclic antidepressant limit its use as a local anesthetic. In this study, comparing the effect of combination of different amitrptyline doses with dexmedetomidine on block initiation and termination time in sciatic nerve blockadge with amitrptyline and bupivacaine alone was aimed. A total of 42 male Sprague-Dawley rats were divided into groups with 7 rats in each. These groups were randomly divided into 6 groups as amitriptyline 0.625 mg (Group 1), amitriptyline 0.312 mg (Group 2), dexmedetomidine 10 μg (Group 3), amitriptyline 0.625 mg and dexmedetomidine 10 μg (Group 4), amitriptyline 0.312 mg and dexmedetomidine 10 μg (Group 5), bupivacaine 0.5% (Group 6). In the right arm with posterior approach, 0.2 mL of local anesthetic was injected with lateral incision . Effectiveness of local anesthetic was determined in terms of motor function, proprioseptive, nosiseptive sensation. In our study, amitriptyline and combination of amitrpityline-dexmedetomidine showed longer local anesthetic effect compared to bupivacaine. Mean block initiation times were shorter in bupivacaine group compared to amitriptyline group though it was not statistically significant. Adding 10 μg of dexmedetomidine to 0.625 mg amitriptyline prolonged block termination times significantly compared to 0.625 mg amitriptyline alone (p

Key words: Sciatic Nerve Blockadge, Amitriptyline, Dexmedetomidine, Bupivacaine






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