Home|Journals|Articles by Year|Audio Abstracts

Original Research

Enzalutamide restores the testosterone effect on H19 expression in prostate cancer cells but not in exosomes

Emre Özgür,Ugur Gezer.

Cited by 2 Articles

Aim: Cellular or exosomal expression of an oncofetal lncRNA gene H19, was evaluated during androgen stimulation via dihydrotestosterone (DHT) or androgen receptor (AR) blockage via enzalutamide in cultured hormone-sensitive prostate cancer (PCa) cells which overexpress the androgen receptor (LNCaP-AR+) in the present study.
Material and Methods: Cells were treated using DHT (10 nM) and/or enzalutamide (10 uM) for 24 hours. Cellular, and exosomal expression of H19 was investigated using a quantitative polymerase chain reaction assay.
Results: Our findings revealed that the mean cellular H19 expression decreased approximately 2.3 fold after androgen stimulation of PCa cells. Enzalutamide restored DHT effect with AR blockage, and we found increased H19 expression with the combined use of DHT, and enzalutamide compared with the levels in the control cells (p

Key words: Prostate cancer; exosomes; H19; androgen; enzalutamide.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.