Name of the article:
Study of alteration in common laboratory parameters in methanol poisoning cases: lesson learned from the hooch tragedy that took place in Ahmedabad, Gujarat.
Objective of the study:
Measurement of methanol in blood is important to confirm the diagnosis of methanol intoxication and can be valuable in assessing the response to treatment. However, blood methanol is measured using gas chromatography in specialty laboratories, and the measurement can take many hours to a few days to complete. Hence we tried to find surrogate makers of acute methanol poisoning that are easily available in most of the settings and any physician can treat such cases in tragic situations like that happened at this study centre.
Retrospective cased based study of cases affected by hooch tragedy.
Method: we collected all the data from the case papers retrospectively.
All laboratory parameters are of the first sample collected after arriving in ED. Correlation of various biochemical parameters was done with respect to serum methanol level to find out the significant correlation. The parameters we studied were serum potassium, amylase, SGPT, random blood sugar level, WBC count, blood indices, arterial pH, arterial bicarbonate. We compared them with serum methanol level.
Data was analysed using epi2000 software. ANOVA, a Parametric Test for Inequality of Population Means or Mann-Whitney/Wilcoxon Two-Sample Test (Kruskal-Wallis test for two groups) as and when required were applied. Variables are expressed as mean±SD, and P
Key words: hooch tragedy, methanol, Gujarat, laboratory parameters