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Profile of CD4 count and troponin i level in HIV patient obtaining triple fixed dose combination (FDC) anti-retroviral therapy

Ummul Ummul Khair, Haerani Rasyid Rasyid, Syakib Bakri, Hasyim Kasim, Makbul Aman, Sudirman Katu, Arifin Seweng, Idar Mappangara.


Background: Human immunodeficiency virus (HIV) is the cause agent of Acquired Immunodeficiency Syndrome (AIDS). HIV can attack various organs such as hear, kidney and suppress the immune system. There are cardiovascular manifestation related to HIV as follow: dilated cardiomyopathy, myocarditis, coronary heart disease, and pericardial effusion. Troponin I has bigger sensitivity and specificity than CKMB and it can detect the presence of new myocardial infarction for up to 2 weeks.
Method: This research was conducted in inpatient and outpatient installation of RSUP dr. Wahidin Sudirohusodo and Laboratory of Clinical Pathology of dr.Wahidin Sudirohusodo Hospital Makasar in October 2018 to December 2018 until the sample was qualified.
Result: The averae of CD4 was found higher in troponin subject of I >= 0,01 (378,7) than troponin subject of I 0,05) statistically. Troponin of I 0,01 was detected to have 3 people with p value 0.566. Thus, it was not significant statistically.
Discussion: This research was obtained statistically and non-statistically because researched subject of patient with HIV were stable without complicating factor such as cardiac abnormalities in inpatient and outpatient at RS Wahidin Sudirohusodo. Respondents aged of 38-39 years had inflammation in group who were infected HIV for the risk of cardiovascular atherosclerosis on average at 69 years of age. In other word, troponin I was most detected in old age. Cardiovascular disease is the leading cause of morbidity and mortality in an individual with HIV infection.

Key words: Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Troponin I, Cluster of Differentiation 4.

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